In people with MEN 1 multiple tumors occur in glands of the endocrine system. A family history of multiple endocrine neoplasia, type 1 (MEN 1), increases the risk of carcinoid tumors. Women are more likely than men to develop carcinoid tumors. Older adults are more likely to be diagnosed with a carcinoid tumor than are younger people or children. Risk factorsįactors that increase the risk of carcinoid tumors include: Some hormones that are produced by neuroendocrine cells are histamine, insulin and serotonin. They perform some nerve cell functions and some hormone-producing endocrine cell functions.
Neuroendocrine cells are found in various organs throughout the body. But they know that carcinoid tumors develop in neuroendocrine cells. Cancer cells can invade nearby healthy tissue and spread to other parts of the body.ĭoctors don't know what causes the mutations that can lead to carcinoid tumors. The mutations allow the cell to continue growing and dividing when healthy cells would normally die. In general, cancer occurs when a cell develops mutations in its DNA. chap 15.It's not clear what causes carcinoid tumors. Melmed: Williams Textbook of Endocrinology. Pituitary Physiology and Diagnostic Evaluation. Philadelphia, Pa: Elsevier Saunders 2011. Henry's Clinical Diagnosis and Management by Laboratory Methods. Greenspan's Basic & Clinical Endocrinology. 4(2):739-69.Īppendix: Normal Hormone Reference Ranges. Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia. Treatment of Cushing's disease: a mechanistic update.
Clinical Manifestation of Hypercalcemia Caused by Adrenal Insufficiency in Hemodialysis Patients: A Case-series Study. Sakao Y, Sugiura T, Tsuji T, Ohashi N, Yasuda H, Fujigaki Y, et al. 2014 Jun 20.Ĭrowley R, Argese N, Tomlinson J, Stewart P. A comparison of low-dose ACTH, glucagon stimulation and insulin tolerance test in patients with pituitary disorders. Simsek Y, Karaca Z, Tanriverdi F, Unluhizarci K, Selcuklu A, Kelestimur F. Mosby's Diagnostic & Laboratory Test Reference.
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